I have listed on this slide the key principles used in selecting and initiating
EDB studies. We try to maximize the number of elements in any one study The
first three are very important, especially for etiological research including
the identification of hypotheses to be tested and the nature of the population.
Where possible, we sample from enumerated population bases, such as using
Medicare lists since they provide more relevant risk estimates. The advantages
in doing longitudinal studies in aging research is well accepted. But also there
is the inclusion of a wide range of variables including data from early life. In
this case risk for diseases, such as Alzheimer’s disease, are likely to be
life-long. Diversity in our studies allows us to take advantage of the
variability in exposure and life-experience. Finally, again, we look for the
potential for addressing applied questions with public health potential.