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Physical activity and obesity interact in the development of Type 2 diabetes. A study of college alumni of University of Pennsylvania shows that the higher the BMI, the higher the incidence of diabetes at each level of physical activity. Conversely, the higher the level of physical activity, the lower the risk of developing diabetes at any BMI level. There is an interaction between the extent of obesity(BMI) and extent of physical activity such that persons with high BMI and low activity have the highest incidence of diabetes, and vice versa.