The fact that liver biopsy is carried out using a fine needle does not guarantee the confirmation of the diagnosis of a macrondular cirrhosis due to nodes larger than 3 mm and uneven distribution of regenerating nodes. In this case, the biopsy may reveal minor fibrous changes and normal liver lobules. It is known that it is much harder to draw fibrous tissue in the needle and the bioptate may contain an insufficient amount of fibrous tissue. The value of the biopsy is also limited by the variable quality of the obtained sample of liver tissue that should be at least 10 mm a length [9]. Due to this, the obtained biological material could be unfit for the diagnosis purposes [33]. Besides, for a number of patients, it is virtually impossible to perform liver biopsy due to some contraindications, such as hemophilia, liver hemangioma, thrombocytopenia, mental instability with phobias, etc. Thus, the applicability of liver biopsy is limited by potential serious complications up to the lethal ones, sampling errors, interobserver variability, and errors in the interpretation of the results.