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NSCLC can differentiate into:

Squamous cell lung cancer

Non-squamous cell tumors without neuroendocrine features (80%);

Non-squamous cell tumors with neuroendocrine cell features (20%).

The recogntion of neuroendocrine features within this subgroup is important in that this group NE-NSCLC

(neuroendocrine non-small cell lung cancer) should probably be treated with post-operative adjuvant chemotherapy.