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Injection of long-acting oxytetracycline at the rate of 10 mg/lb or 22/kg of body weight for 4 treatments at 3-day intervals is also used.

Treated cattle must not be processed for food for at least 28 days after the last treatment.

Once an anaplasmosis-free herd is obtained, all herd additions must be either natural increases, be from anaplasmosis-free herds, or be tested negative or cleared before adding to the herd. Management practices must be adequate to prevent intermingling with other cattle. To assure a disease-free status, some of the herd must be retested annually with negative results.