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Because the US (California ) already codes stage of disease at diagnosis with SEER’s (Surveillance, Epidemiology and End Results program) extent of disease (EOD) coding scheme, to maximize between-country comparability on disease/stage definitions it will be used to stage the samples of Canadian cancer cases.

We will also be able to explore analyses with other staging systems: TNM (tumor-nodes-metastases) for both breast and colon cancer, and Dukes stages and other subsite analyses (e.g., proximal vs. distal) for colon cancer.