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Study:   VACSDM     
Intervention: Intensive(insulin and sulphonylurea)
therapy in type 2 diabetes
Result: Borderline increased cardiovascular risk,especially if no h/o CVD

Study:   UKPDS
Intervention: Intensive (insulin and sulphonylurea)
therapy
Result: Borderline reduction in risk of myocardial infarction (p=0.052)

Study:   UKPDS
Intervention: Metformin in obese subjects
Result: Significant reduction in risk of myocardial infarction (p=0.01)