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Biography |
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Dr. Hussain, senior scientist and Nanotoxicology Group Lead, Molecular Bioeffects Division, Wright-Patterson Air Force Base, Ohio. Dr. Hussain is a fully affiliated professor of Pharmacology and Toxicology, Wright State School of Medicine, Dayton, Ohio. Dr. Hussain began (1987) his scientific career as a toxicology research fellow at the highly regarded Indian Institute of Chemical Technology (IICT) and received his doctorate degree (PhD) in 1991. His novel exploration of heavy metal biotransfer between different proteins in complex biological environment led to a series of prestigious research fellowships in Italy, Switzerland, and the US. Dr. Hussain joined the Air Force Research Laboratory at Wright-Patterson AFB in 1999, where his research interests transitioned into elucidating fundamental interaction of engineered nanomaterials with biological systems, with a special focus on developing nanodevices and evaluating potential toxicity arising from the physicochemical properties of nanoscale structures. He is currently an associate editor of Toxicological Sciences and serves as an editorial member of several other toxicology journals including Nanotoxicity Journal. He is a Fellow of the Academy of Toxicological Sciences and Fellow of the US Air Force Research Laboratory. He serves as an expert reviewer for several government and private organizations. Dr. Hussain has been the recipient of the SOT-AstraZeneca Traveling Lectureship Award and numerous other scientific awards and has established a strong collaborative network with more than 25 organizations of national and international repute. His research related to toxicology of metals and nanomaterials has resulted in author/co-authorship of over 120 peer-reviewed publications, several book chapters, and more than 200 technical abstracts.
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Abstract |
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Evaluation of Engineered Nanomaterial Toxicity & Safety: Linking Materials Physical Parameters |
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Nanomaterials (NMs) possess tremendous promise to advance consumer, military, and medical applications due to enhanced surface area, tunable size, modifiable surface chemistry, and particle reactivity. However, these same properties have made NMs a potential health hazard, thus giving rise to the field of nanotoxicology, which has become prevalent in toxicological advancements and research over the past decade. Through advances in material science, enhanced capabilities have been developed that allow for the reproducible synthesis of distinctive NMs along with a means to accurately assess their physical characteristics. While many early challenges that faced nanotoxicology have been overcome, there are still a number of constraints plaguing the field today. Some of these concerns are emerging as new research areas in nanotoxicology; including NM behavior in a physiological environment, varied aggregate structure, role of ionic dissolution, and realistic modes of exposure. To address these challenges, critical efforts are underway to improve characterization capabilities, identify the optimal metric for NM dosimetry and means of delivery, and development of enhanced cell models for in situ cell studies. This presentation will provide an overview of progress made and challenges associated with each of these efforts, suggest potential solutions to current limitations, and propose standardized requirements to provide future nanotoxicology advancements. |
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