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Biography |
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British citizen. Academic and professional background: BA, MA, Ph.D., Sc.D (Cantab). Main fields: Explanation of function in terms of 3d structure. Macromolecular mimicry and molecular mechanism of protein synthesis. Molecular and cellular mechanism of agiing. Use of phage display to identify differential cellular gene expression and to characterize mutant proteins. Molecular mechanism of disease including cancer and age-related diseases. Career: 1961-62, Research Associate in Division of Biochemistry at M.I.T. Cambridge, USA. 1962-64, Visiting Fellow in Dr. M.W. Nirenberg's Section of Biochemical Genetics, National Heart Institute, N.I.H., Bethesda, Maryland, USA. 1964-74, Member of Scientific Staff, Medical Research Council, Laboratory of Molecular Biology, Cambridge; Member of division of cell biology under the direction of Francis Crick & Sydney Brenner. 1974-2006 , Professor of bio-structural chemistry at The University of Aarhus, Denmark. Chief Scientific Officer Senetek PLC 2006, 2006 Emeritus Professor. Publications: 200 publications, including five books. Achievements: discovery of the initiation codon for protein synthesis and hence start of protein coding (1965-66); first crystallization of tRNA (1968); Co-founder of Senetek PLC (1983) determination of the first structure of a GTP-binding protein (1985); structural determination of the ternary complex (1995). Coordinator of EU Integrated Project PROTEOMAGE involving 19 partners in Europe and China.
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