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Unless the herd has a guaranteed health security, then danger from BVDV is ever present. In fact, some of the largest and most damaging outbreaks have occurred in so-called 'closed' herds. The retention of PI animals as sentinel vaccinators for young stock has been suggested but this can actually cause disease rather than prevent it.

The best way forward is to vaccinate females of breeding age before they are inseminated. This will prevent the considerable reproductive loss due to the virus, ensure that unborn calves are not prematurely exposed to BVDV and become persistently infected. This will, in turn, remove the main reservoir of viral infection for other cattle.