A framework for managing a comprehensive Global Access Strategy is presented based on experiences from public-private product-development partnerships in health. It is aimed at strengthening the ability of public-sector entities to reach their goals. Examples will be given from efforts to accelerate vaccine development and distribution to meet the health needs of the world’s poor and how these efforts tie in with best practices in intellectual property management as a tool to achieve global access. Best practices in a broader context include: • enactment of comprehensive—and appropriate—national laws and policies • formulation of institutional IP policies and effective IP management strategies • application of creative licensing practices that ensure global access and affordability • building institutional IP management capabilities • the creation of functioning national IP systems that include efficient patent offices and transparent IP court systems. Relying on the application of innovation theory, the strategy leads to the identification of six Components of Innovation which cover all aspects of the vaccine innovation process. Appropriately modified, the proposed framework can be applied to the development and introduction of other products in developing countries including nutritional and agricultural products.