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Biography |
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Education: Faculty of Chemistry, Chemical Kinetics Department, Lomonosov State University (Moscow) – 1968
Ph.D. degree (Chemical Kinetics, Chemical Enzymology) – 1971
Doctor of Science (Chemistry) – 1979
Member of the Russian Academy of Sciences – 2006
Honors, awards:
The Lomonosov Prize for Science and Technology – 2000
The National Prize for Science and Technology – 1974, 1984
Professional appointments:
Junior researcher, Biokinetics Department, A.N.Belozersky Interfaculty Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State Univer. –1971-1973.
Assistant Professor, Chemical Kinetics Depart., Faculty of Chemistry, Moscow State Univer. – 1973-1974.
Senior researcher, Chemical Enzymology Depart., Faculty of Chemistry, Moscow State Univer. – 1974-1978.
Professor, Head of Biokinetics Depart., A.N. Belozersky Interfaculty Laboratory for Molecular Biology and Bioorganic Chemistry, Moscow State Univer. – 1978-1987.
Professor, Head of Chemical Enzymology Dep., Faculty of Chemistry, Moscow State Univer. – 1987–present
Director, Institute of Biochemical Physics, Russian Academy of Sciences – 2004–present
SPECIALIZATION
(i) the main fields: physico-chemical biology; biocatalysis, chemical and biological kinetics, enzymology biotechnology, biokinetics.
(ii) other fields: microbiology
(iii) current research interests: enviromental biotechnology, biosensors, genetic engineering of enzymes, biofuels.
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Abstract |
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Human Genetic Variation as Structural and Functional Diversity of Biomacromolecules. The Pathway to Individual Medicine.
Results of Russian project 2005-2007.
Sergey Varfolomeev
Institute of Biochemical Physics,
Russian Academy of Sciences, Moscow State University
Genomics, proteomics, bioinformatics and post-genomic chemistry open the new area in biomedical research. Modern methodology of analysis of structural particularities of DNA and proteins for individuals is based on enzyme technologies, DNA genes amplification, mass-spectrometry of biomacromolecules. The options and trends in research methods are discussed in details. The special interesting results were obtained in protein analysis of exalted air condensate. In Russia was organized the project “Human polymorphism” with participation of Moscow State University and key research groups of Russian Academy of Sciences. The structural diversity of DNA (SNP analysis) and proteins was analyzed for different systems of human organism, including the genetic, proteomic and catalytic polymorphism of enzymes, ribosome DNA, DNA retroelements and others. The research is focused on the analysis of predispositions of individuals for diseases on genetic and protein level. The results are the basis for development of cardiogenomics, oncologenomics, pharmocologenomics and grounds for fundamental understanding of illnesses and pathologies. Special Russian peculiarity is the multy-national structure of the society. The fundamental results were obtained in the field of the ethnogenomics and ethnogeography.
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