We have looked at some data suggesting that the variability of individual schedules is an important determinant of whether or not patients adhere to treatment. These data were taken from a study where we looked at strategies to promote adherence among individuals who are on either or placebos and participating in a clinical research study. We found a statistically significant difference between regularities of bedtime routine and taking the medication, which has been prescribed to be taken in the evening, either at dinner time or at bedtime. The rest of the day didn't matter. If you look at how regular people live their lives, you find a very strong predictive relationship around the time that they need to be carrying out the regimen. For these folks, it didn't matter where they were. We often talk about the problem of people traveling or having meetings or doing other kinds of things that disrupt their schedule. We didn't find that to be as problematic as not having the same routine for going to bed, no matter where you were going to bed.